منابع مشابه
Behavioral Changes in Mice Lacking Interleukin-33
Interleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is expressed in nuclei and secreted as alarmin upon cellular damage to deliver a danger signal to the surrounding cells. Previous studies showed that IL-33 is expressed in the brain and that it is involved in neuroinflammatory and neurodegenerative processes in both humans and rodents. Nevertheless, the role of IL-33 in phys...
متن کاملThe Role of Interleukin-33 in Rhinitis
IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine ...
متن کاملIL-33 promotes gastrointestinal allergy in a TSLP-independent manner
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tes...
متن کاملInterleukin-33: a regulator of basophils.
The cytokine network controlling basophils has been extended to interleukin-33. This commentary provides an update and summary on this emerging concept.
متن کاملInterleukin-33 Prevents Apoptosis and Improves Survival
BackgroundST2 is an interleukin-1 receptor family member with membranebound (ST2L) and soluble (sST2) isoforms, and, sST2 is a biomarker for poor outcome in patients with myocardial infarction (MI). IL-33, the recently-discovered ligand for ST2, activates NF-kB and thus may regulate apoptotic cell death. We tested the hypothesis that IL-33 is cardioprotective after MI through ST2 signaling. Met...
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ژورنال
عنوان ژورنال: Allergy
سال: 2012
ISSN: 0105-4538
DOI: 10.1111/all.12004